AR03 (BMH-23, AR03, Ape1 repair inhibitor 03) | APE1 inhibitor

Chemical Structure : AR03

CAS No.: 510721-85-4

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AR03 (AR-03, BMH-23, Ape1 repair inhibitor 03)

货号: PC-60677Not For Human Use, Lab Use Only.

AR03 (BMH-23, AR03, Ape1 repair inhibitor 03) is a novel small molecule inhibitor of DNA repair protein apurinic/apyrimidinic endonuclease 1 (APE1) endonuclease activity with IC50 of 5 uM.

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10 mg	￥2180	In stock
25 mg	￥3780	In stock
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生物&药学活性

AR03 (BMH-23, AR03, Ape1 repair inhibitor 03) is a novel small molecule inhibitor of DNA repair protein apurinic/apyrimidinic endonuclease 1 (APE1) endonuclease activity with IC50 of 5 uM.
AR03 shows 8-fold less effectivity in inhibiting endonuclease IV, and no effect on the redox activity of Ape1 or the ability of c-Jun/c-Fos to bind DNA.
AR03 has low affinity for double-stranded DNA and weakly inhibits the Escherichia coli endonuclease IV, requiring a 20-fold higher concentration than for inhibition of Ape1.
AR03 potentiates the cytotoxicity of methyl methanesulfonate and temozolomide in SF767 cells.

物理化学性质&存储条件

分子量	237.306
分子式	C15H15N3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,4,9-trimethylbenzo[b][1,8]-naphthyridin-5-amine

参考文献

1. Bapat A, et al. J Pharmacol Exp Ther. 2010 Sep 1;334(3):988-98.

AR03 (AR-03, BMH-23, Ape1 repair inhibitor 03)

生物&药学活性

物理化学性质&存储条件

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AR03 (AR-03, BMH-23, Ape1 repair inhibitor 03)

生物&药学活性

物理化学性质&存储条件

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