APTO-253 | KLF4 inhibitor | Probechem Biochemicals

Chemical Structure : APTO-253

CAS No.: 916151-99-0

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APTO-253 (APTO253, LOR253, LOR-253)

货号: PC-35075Not For Human Use, Lab Use Only.

APTO-253 (LOR-253) is a small molecule inducer of KLF4, stabilizes G-quadruplex DNA and reduces MYC mRNA expression and protein levels.

规格	价格	库存
1 mg (Free Sample)	￥280	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

APTO-253 (LOR-253) is a small molecule inducer of KLF4, stabilizes G-quadruplex DNA and reduces MYC mRNA expression and protein levels.
APTO-253 is converted intracellularly from a monomer to a ferrous complex [Fe(253)3].
APTO-253 selectively induces CDKN1A (p21), promotes G0-G1 cell-cycle arrest, and triggers apoptosis in acute myeloid leukemia (AML) cells without producing myelosuppression in various animal species and humans, induces DNA Damage in AML cells.

物理化学性质&存储条件

分子量	367.387
分子式	C22H14FN5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(5-Fluoro-2-methyl-1H-indol-3-yl)-1H-imidazo[4,5-f][1,10]phenanthroline

参考文献

1. Tsai CY, et al. Mol Cancer Ther. 2018 Apr 6. doi: 10.1158/1535-7163.MCT-17-0834.

2. Cercek A, et al. Invest New Drugs. 2015 Oct;33(5):1086-92.

3. Wang B, et al. Biochem Biophys Res Commun. 2017 Mar 11;484(3):486-492.

4. Local A, et al. Mol Cancer Ther. 2018 Apr 6. doi: 10.1158/1535-7163.MCT-17-1209.

APTO-253 (APTO253, LOR253, LOR-253)

生物&药学活性

物理化学性质&存储条件

参考文献

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询单

APTO-253 (APTO253, LOR253, LOR-253)

生物&药学活性

物理化学性质&存储条件

参考文献

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