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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Wee1-APO-50815
APO-50815

Chemical Structure : APO-50815

CAS No.: 2272976-28-8

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APO-50815 (APO50815)

货号: PC-26642Not For Human Use, Lab Use Only.

APO-50815 is a potent and selective WEE1 kinase inhibitor with IC50 of 9 nM, 10-fold selective over PLK1 and does not inhibit CHK1.

规格 价格 库存 数量
5 mg ￥1880 In stock
10 mg ￥2980 In stock
25 mg ￥4980 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

APO-50815 is a potent and selective WEE1 kinase inhibitor with IC50 of 9 nM, 10-fold selective over PLK1 and does not inhibit CHK1.
APO-50815 demonstrates exceptional anticancer efficacy against the peritoneal mCRC PDO lines PM003 and PM025 with GI50 of 37 nM and 74 nM respectively.
APO-50815 shows potent activity against TP53-mutated CRC PDO lines derived from liver metastases, abrogate CDK1 phosphorylation in MDA-MB-231HM cancer cells.

物理化学性质&存储条件

分子量 527.65
分子式 C28H29N7O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-allyl-1-(6-(3-hydroxythietan-3-yl)pyridin-2-yl)-6-((2'-methyl-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-7'-yl)amino)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one

参考文献

1. Joel L Syphers, et al. Eur J Med Chem. 2026 Apr 5:312:118838.

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