AMPTX1

Chemical Structure : AMPTX1

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货号: PC-25674Not For Human Use, Lab Use Only.

AMPTX-1 is a potent, selective and reversibly covalent BRD9 degrader with DC50 of 0.5 nM and Dmax =93% (MV4-11 cell, 6h).

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生物&药学活性

AMPTX-1 is a potent, selective and reversibly covalent BRD9 degrader with DC50 of 0.5 nM and Dmax =93% (MV4-11 cell, 6h).
AMPTX-1 covalently recruits DCAF16:DDB1 complex to BRD9.
AMPTX-1-induced BRD9 degradation is dependent on the DCAF16 Cullin RING E3 ligase.
AMPTX-1 induces sustained BRD9 protein degradation in a xenograft model.

物理化学性质&存储条件

分子量	691.92
分子式	C42H53N5O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(5-((7-(2,6-dimethoxy-4-(1,4,5-trimethyl-6-oxo-1,6-dihydropyridin-3-yl)benzyl)-4,7-diazaspiro[2.5]octan-4-yl)methyl)-1-methyl-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-4,4-dimethylpent-2-enenitrile

参考文献

1. Hughes SJ, et al. Nat Commun. 2025 Oct 27;16(1):8516.

AMPTX1

生物&药学活性

物理化学性质&存储条件

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AMPTX1

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物理化学性质&存储条件

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