AMC-3-221

Chemical Structure : AMC-3-221

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货号: PC-28444Not For Human Use, Lab Use Only.

AMC-3-221 is a potent, CDK9-selective PROTAC degrader with DC50 of <10 nM and antileukemic inhibitory potency (IC50<50 nM), shows high selectivity for CDK9 over other family members.

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生物&药学活性

AMC-3-221 is a potent, CDK9-selective PROTAC degrader with DC50 of <10 nM and antileukemic inhibitory potency (IC50<50 nM), shows high selectivity for CDK9 over other family members.

物理化学性质&存储条件

分子量	782.61
分子式	C35H34Cl2FN9O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2,6-dichlorobenzamido)-N-(1-(2-(4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)-2-oxoethyl)piperidin-4-yl)-1H-pyrazole-3-carboxamide

参考文献

1. Chan AM, et al. ACS Pharmacol Transl Sci. 2026 Aug 28;9(9):2560-2584.

AMC-3-221

生物&药学活性

物理化学性质&存储条件

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AMC-3-221

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物理化学性质&存储条件

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