AM6527 | CB1 antagonist | Probechem Biochemicals

Chemical Structure : AM6527

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AM6527 (AM-6527)

货号: PC-21463Not For Human Use, Lab Use Only.

AM6527 is a highly potent, selective cannabinoid CB1 receptor antagonist with binding Ki of 4.88 nM, 100-fold selective over CB2 receptors.

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生物&药学活性

AM6527 is a highly potent, selective cannabinoid CB1 receptor antagonist with binding Ki of 4.88 nM, 100-fold selective over CB2 receptors.
AM6527 shows no affinity against a variety of neurotransmitter related receptors, ion-channels, enzymes and peptides.
AM6527 produced a dose-dependent decrease in responding on FR5 in rates with ED50 of 1.49 mg/kg (orally administered).

物理化学性质&存储条件

分子量	374.46
分子式	C24H23FN2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(5-fluoropentyl)-N-(naphthalen-2-yl)-1H-indole-3-carboxamide

参考文献

1. Limebeer CL, et al. Br J Pharmacol. 2010 Sep;161(2):336-49.

2. Sink KS, et al. Pharmacol Biochem Behav. 2009 Jan;91(3):303-6.

AM6527 (AM-6527)

生物&药学活性

物理化学性质&存储条件

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AM6527 (AM-6527)

生物&药学活性

物理化学性质&存储条件

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