AM1476 hydrochloride | 5-HT2B inhibitor | Probechem Biochemicals

Chemical Structure : AM1476 hydrochloride

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AM1476 hydrochloride (AM-1476 hydrochloride)

货号: PC-28206Not For Human Use, Lab Use Only.

AM1476 hydrochloride is a highly selective 5-HT2B receptor (5-HT2BR) inhibitor with IC50 of 5.8 nM, showed only low activity at the5-HT2AR (IC50 >10 000 nM) and 5-HT2CR.

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生物&药学活性

AM1476 hydrochloride is a highly selective 5-HT2B receptor (5-HT2BR) inhibitor with IC50 of 5.8 nM, showed only low activity at the5-HT2AR (IC50 >10 000 nM) and 5-HT2CR.
AM1476 demonstrated high selectivity for 5-HT2B R over more than 200 otherreceptors including other 5-HT receptors in vitro.

物理化学性质&存储条件

分子量	272.71
分子式	C11H14ClFN4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-3-(4-fluoro-2-hydroxyphenyl)-4-methyl-4,5-dihydro-1H-pyrazole-1-carboximidamide hydrochloride

参考文献

1. Thuong Trinh-Minh, et al. Arthritis Rheumatol. 2025 Aug;77(8):1063-1076.

AM1476 hydrochloride (AM-1476 hydrochloride)

生物&药学活性

物理化学性质&存储条件

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AM1476 hydrochloride (AM-1476 hydrochloride)

生物&药学活性

物理化学性质&存储条件

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