AM-6226 (AM6226) | GPR40 agonist | Probechem Biochemicals

Chemical Structure : AM-6226

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AM-6226 (AM 6226, AM6226)

货号: PC-35199Not For Human Use, Lab Use Only.

AM-6226 (AM6226) is a potent, selective, orally bioavailable GPR40 (FFA1) full agonist with EC50 of 0.12 uM.

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生物&药学活性

AM-6226 (AM6226) is a potent, selective, orally bioavailable GPR40 (FFA1) full agonist with EC50 of 0.12 uM.
AM-6226 displays significant glucose lowering during an oral glucose tolerance test (OGTT) at 1 and 10 mg/kg in prediabetic cynomolgus monkeys.

物理化学性质&存储条件

分子量	522.633
分子式	C32H36F2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-3-(3-((2-((R)-2,2-dimethylcyclopentyl)-2'-fluoro-5'-methoxy-[1,1'-biphenyl]-4-yl)methoxy)-2-fluorophenyl)pentanoic acid

参考文献

1. Sean P. Brown, et al. Discovery of AM-6226: A Potent and Orally Bioavailable GPR40 Full Agonist That Displays Efficacy in Nonhuman Primates. ACS Med. Chem. Lett.,DOI: 10.1021/acsmedchemlett.8b00213

2. Luo J, et al. PLoS One. 2012;7(10):e46300.

AM-6226 (AM 6226, AM6226)

生物&药学活性

物理化学性质&存储条件

参考文献

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AM-6226 (AM 6226, AM6226)

生物&药学活性

物理化学性质&存储条件

参考文献

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