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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Glycine Transporter (GlyT)-ALX-5407 hydrochloride
ALX-5407 hydrochloride

Chemical Structure : ALX-5407 hydrochloride

CAS No.: 200006-08-2

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ALX-5407 hydrochloride (ALX5407)

货号: PC-62960Not For Human Use, Lab Use Only.

ALX-5407 hydrochloride is a potent, selective, orally active inhibitor of GlyT1 glycine transporter with IC50 of 3 nM.

规格 价格 库存 数量
5 mg ￥1380 In stock
10 mg ￥2180 In stock
25 mg ￥3780 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ALX-5407 hydrochloride is a potent, selective, orally active inhibitor of GlyT1 glycine transporter with IC50 of 3 nM.
ALX-5407 has little or no activity at the GlyT2 transporter, at other binding sites for glycine, or at other neurotransmitter transporters.
ALX-5407 increases free glycine levels in rat prefrontal cortex (10 mg/kg, p.o.).

物理化学性质&存储条件

分子量 429.916
分子式 C24H25ClFNO3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-[(3R)-3-([1,1'-Biphenyl]-4-yloxy)-3-(4-fluorophenyl)propyl]-N-methylglycine hydrochloride

参考文献

1. Atkinson BN, et al. Mol Pharmacol. 2001 Dec;60(6):1414-20.

2. Perry KW, et al. Neuropharmacology. 2008 Oct;55(5):743-54.

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