Tanerasertib (ALTA-2618) | AKT1 E17K inhibitor | Probechem Biochemicals

Chemical Structure : ALTA-2618

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ALTA-2618 (Tanerasertib, ALTA2618)

货号: PC-25099Not For Human Use, Lab Use Only.

Tanerasertib (ALTA-2618) is a potent, highly mutant-selective, allosteric AKT1 E17K inhibitor with EC50 of 7 nM, 22-fold selectivity over WT AKT1 and 140-fold selectivity over WT AKT2.

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生物&药学活性

Tanerasertib (ALTA-2618) is a potent, highly mutant-selective, allosteric AKT1 E17K inhibitor with EC50 of 7 nM, 22-fold selectivity over WT AKT1 and 140-fold selectivity over WT AKT2.
ALTA-2618 demonstrated covalent attachment to the AKT1 E17K protein.
ALTA-2618 induced tumor regressions in AKT1 E17K mutant HR+/HER2low breast cancer, TNBC, and endometrial cancer PDXs at doses as low as 10 mg/kg/d.

物理化学性质&存储条件

分子量	597.66
分子式	C33H28FN11
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Pyrimidinecarbonitrile, 4-[[1-[[4-[2-(2-amino-3-pyridinyl)-5-(5-fluoro-2-pyridinyl)-3H-imidazo[4,5-b]pyridin-3-yl]phenyl]methyl]-4-piperidinyl]amino]-

参考文献

1. Eric A. Murphy, et al. Cancer Res (2024) 84 (7_Supplement): LB173.

2. Patent WO2024073371 A1.

ALTA-2618 (Tanerasertib, ALTA2618)

生物&药学活性

物理化学性质&存储条件

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ALTA-2618 (Tanerasertib, ALTA2618)

生物&药学活性

物理化学性质&存储条件

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