ALS-04 | TBK1/ALK inhibitor | Probechem Biochemicals

Chemical Structure : ALS-04

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ALS-04 (ALS04)

货号: PC-24297Not For Human Use, Lab Use Only.

ALS-04 is a potent, dual inhibitor of TBK1 and ALK with IC50 of 378 nM and 9.5 nM respectively, effectively suppressing ALK-AKT signaling via the STING pathway.

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生物&药学活性

ALS-04 is a potent, dual inhibitor of TBK1 and ALK with IC50 of 378 nM and 9.5 nM respectively, effectively suppressing ALK-AKT signaling via the STING pathway.
ALS-04 inhibits cGAMP-induced immune response in THP-1 cells and Raw264.7 cells with IC50 of 1.62 μM and 1.97 μM, Imax of 95.7 % and 98.1 %, respectively.
ALS-04 inhibits cGAMP-induced type I IFN response.
ALS-04 inhibits cGAMP and LPS-induced inflammatory response.
ALS-04 significantly inhibits the secretion of both innate and pro-inflammatory cytokines in response to cGAMP and LPS stimulation in vivo.

物理化学性质&存储条件

分子量	490.96
分子式	C22H23ClN4O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(3-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxyphenyl)acetic acid

参考文献

1. Wi JH, et al. Biomed Pharmacother. 2025 Mar 19;186:117991.

ALS-04 (ALS04)

生物&药学活性

物理化学性质&存储条件

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ALS-04 (ALS04)

生物&药学活性

物理化学性质&存储条件

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