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首页-小分子抑制剂&激动剂-TGF-beta/Smad-TGF beta Receptor (TGFBR)-ALK5 inhibitor 20
ALK5 inhibitor 20

Chemical Structure : ALK5 inhibitor 20

CAS No.: 2921605-02-7

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ALK5 inhibitor 20

货号: PC-26849Not For Human Use, Lab Use Only.

ALK5 inhibitor 20 is a potent, selective and lung-restricted ALK5 inhibitor with pKi of 10.13, shows persistent and lung-restricted target engagement in a pharmacodynamic model, shows remarkable efficacy in idiopathic pulmonary fibrosis (IPF).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

ALK5 inhibitor 20 is a potent, selective and lung-restricted ALK5 inhibitor with pKi of 10.13, shows persistent and lung-restricted target engagement in a pharmacodynamic model, shows remarkable efficacy in idiopathic pulmonary fibrosis (IPF).

物理化学性质&存储条件

分子量 546.06
分子式 C25H29ClFN7O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-((6-(5-chloro-2-fluorophenyl)-3-((2-hydroxyethyl)thio)pyridazin-4-yl)amino)pyridin-2-yl)-3-(4-methylpiperazin-1-yl)propanamide

参考文献

1. Ronchi P, et al. J Med Chem. 2026 May 18. doi: 10.1021/acs.jmedchem.5c03825.

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