AKOS-22 (AKOS22, AKOS-022)

Chemical Structure : AKOS-22

CAS No.: 878983-38-1

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货号: PC-25112Not For Human Use, Lab Use Only.

AKOS-22 (AKOS22, AKOS-022) is a poten, specific mitochondrial protein VDAC1 (voltage-dependent anion channel 1) inhibitor with KD of 15.4 uM.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

AKOS-22 (AKOS22, AKOS-022) is a poten, specific mitochondrial protein VDAC1 (voltage-dependent anion channel 1) inhibitor with KD of 15.4 uM, interacts with VDAC1 and inhibits both VDAC1 oligomerization and apoptosis, protects against mitochondrial dysfunction.

物理化学性质&存储条件

分子量	467.87
分子式	C22H21ClF3N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-chlorophenyl)-3-(4-{[4-(trifluoromethoxy)phenyl]amino}piperidin-1-yl)pyrrolidine-2,5-dione

参考文献

1. Ben-Hail D, et al. J Biol Chem. 2016 Nov 25;291(48):24986-25003.