AIM-100 | Ack1 inhibitor | Probechem Biochemicals

Chemical Structure : AIM-100

CAS No.: 873305-35-2

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AIM-100 (AIM 100, AIM100)

货号: PC-44307Not For Human Use, Lab Use Only.

AIM-100 (AIM100) is a highly potent inhibitor of Ack1 (TNK2) (IC50=24 nM), selective for Ack1 over ABL1, BTK, Lck and LYN.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥2980	In stock
100 mg		Get quote

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生物&药学活性

AIM-100 (AIM100) is a highly potent inhibitor of Ack1 (TNK2) (IC50=24 nM), selective for Ack1 over ABL1, BTK, Lck and LYN.
AIM-100 inhibits Ack1 Tyr284-phosphorylation attenuated pTyr267-AR transcriptional activity which in turn resulted in cell cycle arrest.
AIM-100 inhibits pTyr284 -Ack1 expression, and prostate cancer cell proliferation.

物理化学性质&存储条件

分子量	371.43
分子式	C23H21N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Furo[2,3-d]pyrimidin-4-amine, 5,6-diphenyl-N-[[(2S)-tetrahydro-2-furanyl]methyl]-

参考文献

1. Mahajan K, et al. Prostate. 2010 Sep 1;70(12):1274-85.

2. Mahajan K, et al. Am J Pathol. 2012 Apr;180(4):1386-93.

3. Mahajan K, et al. J Biol Chem. 2012 Jun 22;287(26):22112-22.

4. DiMauro EF, et al. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2305-9.

AIM-100 (AIM 100, AIM100)

生物&药学活性

物理化学性质&存储条件

参考文献

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AIM-100 (AIM 100, AIM100)

生物&药学活性

物理化学性质&存储条件

参考文献

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