AHPC(Me)-C6-NH2 | FBXO22 degrader | Probechem Biochemicals

Chemical Structure : AHPC(Me)-C6-NH2

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AHPC(Me)-C6-NH2 ((S,R,S)-AHPC(Me)-C6-NH2)

货号: PC-25389Not For Human Use, Lab Use Only.

AHPC(Me)-C6-NH2 is a potent, highly selective VHL-recruiting FBXO22 PROTAC degrader with DC50 of 77 nM in Jurkat cells, Dmax = 99%.

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生物&药学活性

AHPC(Me)-C6-NH2 is a potent, highly selective VHL-recruiting FBXO22 PROTAC degrader with DC50 of 77 nM in Jurkat cells, Dmax = 99%.
AHPC(Me)-C6-NH2 exhibits a highly selective degradation profile, with FBXO22 being the only protein efficiently degraded across the entire proteome.
AHPC(Me)-C6-NH2 (1-10 uM) induces robust FBXO22 degradation in THP-1 and HEK293T cells for 24 hours.
AHPC(Me)-C6-NH2 is effective for FBXO22 degradation by engaging C326.
AHPC(Me)-C6-NH2 mimics genetic loss of FBXO22 and serves as a chemical biology tool for probing its function.

物理化学性质&存储条件

分子量	571.78
分子式	C30H45N5O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,4R)-1-((S)-2-(7-aminoheptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide

参考文献

1. Tian Qiu, et al. bioRxiv [Preprint]. 2025 Aug 20:2025.08.19.671158.

AHPC(Me)-C6-NH2 ((S,R,S)-AHPC(Me)-C6-NH2)

生物&药学活性

物理化学性质&存储条件

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AHPC(Me)-C6-NH2 ((S,R,S)-AHPC(Me)-C6-NH2)

生物&药学活性

物理化学性质&存储条件

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