AGS8-IN-1

Chemical Structure : AGS8-IN-1

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货号: PC-26054Not For Human Use, Lab Use Only.

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生物&药学活性

AGS8-IN-1 is a small molecule inhibitor of activator of G-protein signaling 8 (AGS8), effectively inhibits the formation of the AGS8-Gβγ complex, attenuates VEGF-induced phosphorylation of signaling molecules and inhibits tube formation and migration of HUVECs.
AGS8-IN-1 inhibits the growth of AGS8-expressing yeast in a dose-dependent manner with IC50 of 20 uM.
AGS8-IN-1 blocks the interaction between AGS8C and Gβγ.
AGS8-IN-1 attenuates the phosphorylation of VEGFR2.
AGS8-IN-1 attenuates VEGF-mediated tube formation and migration of HUVECs.

物理化学性质&存储条件

分子量	491.54
分子式	C23H17N5O4S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[2-[3-methyl-5-oxo-1-(4-phenyl-1,3-thiazol-2-yl)pyrazol-4-ylidene]hydrazinyl] naphthalene-1-sulfonic acid

参考文献

1. Hossain A, et al. J Physiol Sci. 2026 Feb 3;76(1):100064.

AGS8-IN-1

生物&药学活性

物理化学性质&存储条件

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AGS8-IN-1

生物&药学活性

物理化学性质&存储条件

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