AGPAT4 inhibitor CL26

Chemical Structure : AGPAT4 inhibitor CL26

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货号: PC-25223Not For Human Use, Lab Use Only.

AGPAT4 inhibitor CL26 is a potent, isoform-specific, covalent inhibitor of acylglycerol-3-phosphate o-acyltransferase 4 (AGPAT4) inhibitor with IC50 of 795 nM, binds to Cys228 of AGPAT4.

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100 mg		Get quote

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生物&药学活性

AGPAT4 inhibitor CL26 is a potent, isoform-specific, covalent inhibitor of acylglycerol-3-phosphate o-acyltransferase 4 (AGPAT4) inhibitor with IC50 of 795 nM, binds to Cys228 of AGPAT4.
CL26 exhihits specificity toward AGPAT4 over other AGPAT LPAAT family members.
CL26 binds covalently to Cys228 and noncovalently to Trp106 and Trp136 through π-π interactions.
CL26 exhibits synergistic effect of combining sorafenib in high AGPAT4-expressing MHCC97L and MHCC97H cells, the C228A mutant does not exhibit resistance to sorafenib nor show synergy with CL26.
CL26 sensitizes HCC tumors to eradication by sorafenib treatment with no evidence of toxicity in HCC PDX model.

物理化学性质&存储条件

分子量	306.76
分子式	C14H11ClN2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((5-(benzo[d]thiazol-2-yl)furan-2-yl)methyl)-2-chloroacetamide

参考文献

1. Ng KY, et al. Sci Transl Med. 2025 Jul 30;17(809):eadn9472.