AGI-24512 | MAT2A inhibitor | Probechem Biochemicals

Chemical Structure : AGI-24512

CAS No.: 2201066-53-5

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AGI-24512 (AGI 24512, AGI24512)

货号: PC-25274Not For Human Use, Lab Use Only.

AGI-24512 is a highly potent, cell-active methionine adenosyltransferase 2α (MAT2A) inhibitor with enzymatic IC50 of 8 nM.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
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100 mg		Get quote

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生物&药学活性

AGI-24512 is a highly potent, cell-active methionine adenosyltransferase 2α (MAT2A) inhibitor with enzymatic IC50 of 8 nM.
AGI-24512 reduces cellular S-adenosylmethionine levels, S-adenosylmethionine de novo biosynthesis, and symmetric dimethyl arginine levels.
AGI-24512 selectively reduces growth of MTAP−/− cancer cells, with limited effects on MTAP WT lines.
AGI-24512 induces MTAP−/− genotype-selective cell-cycle delays and DNA damage.
AGI-24512 affected multiple alternative splicing events in MTAP−/− but not in WT cells, affects PRMT5 downstream splicing biology.

物理化学性质&存储条件

分子量	400.48
分子式	C24H24N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(4-Hydroxyphenyl)-5-methyl-2-phenyl-3-(piperidin-1-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one

参考文献

1. Kalev P, et al. Cancer Cell. 2021 Feb 8;39(2):209-224.e11.

2. Konteatis Z, et al. J Med Chem. 2021 Apr 22;64(8):4430-4449.

AGI-24512 (AGI 24512, AGI24512)

生物&药学活性

物理化学性质&存储条件

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AGI-24512 (AGI 24512, AGI24512)

生物&药学活性

物理化学性质&存储条件

参考文献

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