AG17724 | Pin1 inhibitor | Probechem Biochemicals

Chemical Structure : AG17724

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AG17724 (Pin1 inhibitor DMS)

货号: PC-49154Not For Human Use, Lab Use Only.

AG17724 (Pin1 inhibitor DMS) is a selective inhibitor of prolyl isomerase Pin1 with Ki of 0.03 uM, DMS functionalized with CAF-targeting anti-FAP-α antibodies (antiCAFs-DMS) can selectively inhibit Pin1 in CAFs, leading to efficacious but transient tumor growth inhibition.

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生物&药学活性

AG17724 (Pin1 inhibitor DMS) is a selective inhibitor of prolyl isomerase Pin1 with Ki of 0.03 uM, DMS functionalized with CAF-targeting anti-FAP-α antibodies (antiCAFs-DMS) can selectively inhibit Pin1 in cancer associated fibroblasts (CAFs), leading to efficacious but transient tumor growth inhibition.

物理化学性质&存储条件

分子量	377.38
分子式	C21H16FN3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-(2-Naphthamido)-3-(6-fluoro-1H-benzo[d]imidazol-2-yl)propanoic acid

参考文献

1. Jiaye Liu, et al. Nat Commun. 2022 Jul 25;13(1):4308.

AG17724 (Pin1 inhibitor DMS)

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物理化学性质&存储条件

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AG17724 (Pin1 inhibitor DMS)

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