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首页-小分子抑制剂&激动剂-Others-Other Targets-AEPU
AEPU

Chemical Structure : AEPU

CAS No.: 776300-69-7

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AEPU

货号: PC-25595Not For Human Use, Lab Use Only.

AEPU is a moderately water soluble, orally-available, highly potent and selective soluble epoxide hydrolase (sEH) inhibitor with IC50 of 14 nM (human sEH), reduces the development of atherosclerosis in apolipoprotein e-knockout mouse model.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

AEPU is a moderately water soluble, orally-available, highly potent and selective soluble epoxide hydrolase (sEH) inhibitor with IC50 of 14 nM (human sEH), reduces the development of atherosclerosis in apolipoprotein e-knockout mouse model.

物理化学性质&存储条件

分子量 396.57
分子式 C22H40N2O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-Adamantanyl-3-[5-[2-(2-ethoxyethoxy)ethoxy]pentyl]urea

参考文献

1. Ulu A, et al. J Cardiovasc Pharmacol. 2008 Oct;52(4):314-23.

2. Liu JY, et al. Biochem Pharmacol. 2015 Dec 15;98(4):718-31.

3. Kim IH, et al. J Med Chem. 2007;50:5217–5226.

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