ADRIANA | α2B adrenoceptor antagonist | Probechem Biochemicals

Chemical Structure : ADRIANA

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ADRIANA (c545, Adrenergic inducer of analgesia)

货号: PC-25232Not For Human Use, Lab Use Only.

ADRIANA (c545) is a potent, orally active α2B adrenoceptor subtype-specific antagonist with binding Ki of 987 nM, >50-fold selective over α2A adrenoceptor.

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生物&药学活性

ADRIANA (c545) is a potent, orally active α2B adrenoceptor subtype-specific antagonist with binding Ki of 987 nM, >50-fold selective over α2A adrenoceptor.
ADRIANA shows no binding affinity for αl-adrenergic receptors in radioligand binding assay.
ADRIANA specifically promotes noradrenaline release in the murine spinal dorsal horn and produces analgesic effects by stimulating the α2A-dependent pain inhibitory pathway.
ADRIANA shows potent analgesic effects in several nociceptive pain models of mice and nonhuman primates without cardiovascular effects.

物理化学性质&存储条件

分子量	237.29
分子式	C12H12FNOS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-1-(3-ethyl-5-fluorobenzo[d]thiazol-2(3H)-ylidene)propan-2-one

参考文献

1. Toyomoto M, et al. Proc Natl Acad Sci U S A. 2025 Aug 12;122(32):e2500006122.

ADRIANA (c545, Adrenergic inducer of analgesia)

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物理化学性质&存储条件

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ADRIANA (c545, Adrenergic inducer of analgesia)

生物&药学活性

物理化学性质&存储条件

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