ACY-957 |CAS:1609389-52-7 Probechem Biochemicals

Chemical Structure : ACY-957

CAS No.: 1609389-52-7

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ACY-957 (ACY957)

货号: PC-35363Not For Human Use, Lab Use Only.

ACY-957 (ACY957) is a potent, selective inhibitor of HDAC1 and HDAC2 with IC50 of 7 and 18 nM, shows limited activity against HDAC3 (IC50=1,300 nM) and no activity against HDAC4/5/6/7/8/9 (IC50>20 nM).

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5 mg	￥2580	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
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100 mg		Get quote

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生物&药学活性

ACY-957 (ACY957) is a potent, selective inhibitor of HDAC1 and HDAC2 with IC50 of 7 and 18 nM, shows limited activity against HDAC3 (IC50=1,300 nM) and no activity against HDAC4/5/6/7/8/9 (IC50>20 nM).
ACY-957 elicits dependent induction of γ-globin mRNA (HBG) and HbF protein in a variety of primary erythroid progenitor cell culture system.
ACY-957 increases GATA2 expression, elevates histone acetylation at well-known GATA2 autoregulatory regions.

物理化学性质&存储条件

分子量	429.542
分子式	C24H23N5OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[2-Amino-5-(2-thienyl)phenyl]-2-(1-piperazinyl)-6-quinolinecarboxamide

参考文献

1. Shearstone JR, et al. PLoS One. 2016 Apr 13;11(4):e0153767.

ACY-957 (ACY957)

生物&药学活性

物理化学性质&存储条件

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ACY-957 (ACY957)

生物&药学活性

物理化学性质&存储条件

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