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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-ACX-801
ACX-801

Chemical Structure : ACX-801

CAS No.:

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ACX-801 (ACX801)

货号: PC-25701Not For Human Use, Lab Use Only.

ACX-801 is a potent specific antibiotic for Gram-positive priority pathogens targeting the PolC DNA polymerase (IC50=5.8 uM, E. faecium PolC), demonstrates potent activity against drug-resistant priority pathogens (VRE, MRSA and PRSP), with no activity against Gram-negative bacterium E. coli.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

ACX-801 is a potent specific antibiotic for Gram-positive priority pathogens targeting the PolC DNA polymerase (IC50=5.8 uM, E. faecium PolC), demonstrates potent activity against drug-resistant priority pathogens (VRE, MRSA and PRSP), with no activity against Gram-negative bacterium E. coli.
ACX-801 shows selective inhibition of E. faecium PolC, with no significant inhibition observed against DnaE-type DNA polymerases: Pol IIIα from E. coli33,34 and DnaE of E. faecium.
F1276 position of PolC shows susceptibility to ACX-801 both in vivo and in vitro.

物理化学性质&存储条件

分子量 383.29
分子式 C15H12F3N5O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-(((2,2-difluorobenzo[d][1,3]dioxol-5-yl)methyl)amino)-3-fluoro-1-(2-hydroxyethyl)-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one

参考文献

1. Urem M, et al. Nat Commun. 2025 Nov 6;16(1):9784.

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