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首页-小分子抑制剂&激动剂-GPCR-Chemokine Receptor (CCR and CXCR)-ACT-777991
ACT-777991

Chemical Structure : ACT-777991

CAS No.: 1967811-46-6

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ACT-777991 (ACT777991)

货号: PC-20096Not For Human Use, Lab Use Only.

ACT-777991 (ACT777991) is a highly potent and selective CXCR3 antagonist with IC50 of 33 nM.

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2 mg ￥2580 In stock
5 mg ￥4280 In stock
10 mg ￥7280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ACT-777991 (ACT777991) is a highly potent and selective CXCR3 antagonist with IC50 of 33 nM.
ACT-777991 showed dose-dependent efficacy and target engagement in a mouse model of acute lung inflammation.

物理化学性质&存储条件

分子量 550.48
分子式 C20H20F6N8O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-1-(2-(2-hydroxyethyl)-4-(2-(trifluoromethyl)-4-(2-(trifluoromethyl)pyrimidin-5-yl)thiazol-5-yl)piperazin-1-yl)-2-(3-methyl-1H-1,2,4-triazol-1-yl)ethan-1-one

参考文献

1. Meyer EA, et al. J Med Chem. 2023 Mar 8. doi: 10.1021/acs.jmedchem.3c00074.

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