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首页-小分子抑制剂&激动剂-GPCR-Formyl peptide receptor (FPR)-ACT-389949
ACT-389949

Chemical Structure : ACT-389949

CAS No.: 1258417-54-7

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ACT-389949 (ACT389949)

货号: PC-62594Not For Human Use, Lab Use Only.

ACT-389949 (ACT389949) is a novel potent and selective formyl peptide receptor type 2 (FPR2)/Lipoxin A4 receptor (ALX) agonist with EC50 of 3 nM for FPR2/ALX internalization into monocytes.

规格 价格 库存 数量
5 mg ￥2580 In stock
10 mg ￥3980 In stock
25 mg ￥5880 In stock
50 mg Get quote
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ACT-389949 (ACT389949) is a novel potent and selective formyl peptide receptor type 2 (FPR2)/Lipoxin A4 receptor (ALX) agonist with EC50 of 3 nM for FPR2/ALX internalization into monocytes.
ACT-389949 has potential for the treatment of inflammatory disorders.
ACT-389949 is an agonist for FPR2 that triggers functional/signaling repertoires comparable to what has been earlier described for other FPR2 agonists, including neutrophil chemotaxis, granule mobilization and activation of the NADPH-oxidase.
ACT-389949 is as potent as the prototype FPR2 peptide agonist WKYMVM and had the advantage of being resistant to oxidation by MPO-H2O2-halide derived oxidants, as compared to the sensitive WKYMVM.
ACT-389949 include an FPR2-dependent and Gαq-independent transient rise in intracellular Ca2+ and recruitment of β-arrestin in down-stream signals.
ACT-389949 is an excellent tool-compound for further dissection of FPR2-regulated activities in vitro and in vivo.

物理化学性质&存储条件

分子量 428.4
分子式 C20H18F2N6O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-Methyl-5-m-tolyl-oxazole-4-carboxylic acid {2-[4-(1,1-difluoro-ethyl)-oxazol-2-ylmethyl]-2H-[1,2,3]triazol-4-yl}-amide

参考文献

1. Stalder AK, et al. Br J Clin Pharmacol. 2017 Mar;83(3):476-486.
2. Lind S, et al. Biochem Pharmacol. 2019 Aug;166:163-173.

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