ACBI1 | SMARCA2/SMARCA4 PROTAC | Probechem Biochemicals

Chemical Structure : ACBI1

CAS No.: 2375564-55-7

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ACBI1 (SMARCA2/SMARCA4 PROTAC)

货号: PC-73152Not For Human Use, Lab Use Only.

ACBI1 is a potent and cooperative degrader (PROTAC) of BAF ATPase subunits SMARCA2, SMARCA4 and PBRM1 with DC50 of 6 nM, 11 nM and 32 nM, respectively.

规格	价格	库存
5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥4280	In stock
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100 mg		Get quote

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生物&药学活性

ACBI1 is a potent and cooperative degrader (PROTAC) of BAF ATPase subunits SMARCA2, SMARCA4 and PBRM1 with DC50 of 6 nM, 11 nM and 32 nM, respectively.
ACBI1 is composed of a bromodomain ligand, linker, and the E3 ubiquitin ligase von Hippel-Lindau (VHL).
ACBI1 induced antiproliferative effects and cell death caused by SMARCA2 depletion in SMARCA4 mutant cancer cells, and in AML cells dependent on SMARCA4 ATPase activity.

物理化学性质&存储条件

分子量	936.11
分子式	C49H58FN9O7S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	100 mM in DMSO (93.6 mg/mL in DMSO)
Chemical Name/SMILES	(2S,4R)-N-(2-(2-(4-((4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazin-1-yl)methyl)phenoxy)ethoxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide

参考文献

1. Farnaby W, et al. Nat Chem Biol. 2019 Jul;15(7):672-680.

ACBI1 (SMARCA2/SMARCA4 PROTAC)

生物&药学活性

物理化学性质&存储条件

参考文献

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ACBI1 (SMARCA2/SMARCA4 PROTAC)

生物&药学活性

物理化学性质&存储条件

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