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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-Ras-ACA-14
ACA-14

Chemical Structure : ACA-14

CAS No.: 667437-56-1

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ACA-14 (ACA14)

货号: PC-20692Not For Human Use, Lab Use Only.

ACA-14 is a small molecule direct inhibitor of KRAS, impedes the interaction of KRAS with its effector Raf and reduces both intrinsic and SOS-mediated nucleotide exchange rates.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    ACA-14 is a small molecule direct inhibitor of KRAS, impedes the interaction of KRAS with its effector Raf and reduces both intrinsic and SOS-mediated nucleotide exchange rates.
    ACA-14 inhibits signal transduction through the MAPK pathway in cells expressing mutant KRAS and inhibits the growth of pancreatic and colon cancer cells harboring mutant KRAS.

    物理化学性质&存储条件

    分子量 297.31
    分子式 C17H15NO4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-hydroxy-5-(2-phenylcyclopropane-1-carboxamido)benzoic acid

    参考文献

    1. Cynthia V Pagba, et al. ACS Bio Med Chem Au. 2022 Sep 26;2(6):617-626.

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