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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-11β-HSD-ABRL8301
ABRL8301

Chemical Structure : ABRL8301

CAS No.: 2639788-35-3

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ABRL8301 (ABRL-8301)

货号: PC-27651Not For Human Use, Lab Use Only.

ABRL8301 is a 2-methoxyestradiol derivative that reduces 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) expression and increases heme oxygenase-1 (HO-1) levels in fibrosis-relevant cell types, shows anti-fibrotic efficacy, promoting mesenchymal-to-endothelial transition (MEndT) and reducing mesenchymal markers.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

ABRL8301 is a 2-methoxyestradiol derivative that reduces 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) expression and increases heme oxygenase-1 (HO-1) levels in fibrosis-relevant cell types, shows anti-fibrotic efficacy, promoting mesenchymal-to-endothelial transition (MEndT) and reducing mesenchymal markers.
ABRL8301 inhibits NF-κB signaling in macrophages, promotes polarization toward the M2 anti-inflammatory phenotype, and suppresses interleukin-6 expression, contributing to its anti-fibrotic and immunomodulatory effects.
ABRL8301 significantly attenuated PPF in both bleomycin- and radiation-induced mouse models.
ABRL8301 also mitigated radiation-induced skin vascular injury and collagen accumulation.

物理化学性质&存储条件

分子量 582.73
分子式 C31H34O7S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(8R,9S,13S,14S,17S)-2-methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diyl dibenzenesulfonate

参考文献

1. Heo SW, et al. Eur J Pharmacol. 2026 Aug 11:179224.

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