ABBV-467 (ABBV467)

Chemical Structure : ABBV-467

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货号: PC-23834Not For Human Use, Lab Use Only.

ABBV-467 is a highly potent and selective MCL-1 inhibitor with TR-FRET Ki of <0.01 nM, >25,000-fold seletive over other BCL-2 family proteins BCL-XL, BCL-2, BCL-W, and BCL2-A1.

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生物&药学活性

ABBV-467 is a highly potent and selective MCL-1 inhibitor with TR-FRET Ki of <0.01 nM, >25,000-fold seletive over other BCL-2 family proteins BCL-XL, BCL-2, BCL-W, and BCL2-A1.
ABBV-467 potently inhibits tumor cell lines derived from MM (AMO-1, H929) and AML (MV4-11), shows selective inhibition of the human MCL-1–expressing B-cell acute lymphoblastic leukemia variant.
ABBV-467 triggers rapid and mechanism-based apoptosis to MCL-1-dependent tumor cell lines
ABBV-467 as monotherapy or in combination with venetoclax inhibits the growth of xenografts from human hematologic cancers.

物理化学性质&存储条件

分子量	1037.98
分子式	C53H51Cl2FN6O9S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	18,21-Etheno-9,13-metheno-13H-6,14,17-trioxa-2-thia-3,5-diazacyclononadec[cd]indene-7-carboxylic acid, 19,23-dichloro-10-[[2-[4-[(2R)-1,4-dioxan-2-ylmethoxy]phenyl]-4-pyrimidinyl]methoxy]-1-(4-fluorophenyl)-7,8,15,16-tetrahydro-20,22-dimethyl-16-[(4-methyl-1-piperazinyl)methyl]-, (7R,16R)-

参考文献

1. Yuda J, et al. Commun Med (Lond). 2023 Oct 25;3(1):154.

ABBV-467 (ABBV467)

生物&药学活性

物理化学性质&存储条件

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ABBV-467 (ABBV467)

生物&药学活性

物理化学性质&存储条件

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