ABBV-318 | Nav1.7/ Nav1.8 blocker | Probechem Biochemicals

Chemical Structure : ABBV-318

CAS No.: 1802848-94-7

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ABBV-318 (ABBV318)

货号: PC-38662Not For Human Use, Lab Use Only.

ABBV-318 is a small molecule voltage-gated sodium channel Nav1.7/ Nav1.8 blocker with IC50 of 3.8 and 2.8 uM for hNav1.7 and hNav1.8 in FRET assays, respectively.

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5 mg	￥1380	In stock
10 mg	￥2280	In stock
25 mg	￥3880	In stock
50 mg	￥5980	In stock
100 mg		Get quote

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生物&药学活性

ABBV-318 is a small molecule voltage-gated sodium channel Nav1.7/ Nav1.8 blocker with IC50 of 3.8 and 2.8 uM for hNav1.7 and hNav1.8 in FRET assays, respectively.
ABBV-318 shows no activity (IC50 > 30 µM) at known cardiac liability channel Nav1.5, and lack of potency at Nav1.2, Nav1.4, and Nav1.6 (>30 µM for all 3 channels in whole-cell patch clamp EP assay).
ABBV-318 displays robust in vivo efficacy in both inflammatory and neuropathic rodent models of pain.

物理化学性质&存储条件

分子量	405.353
分子式	C20H15F4N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-(3-fluoropyrrolidin-1-yl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)quinolin-2-yl)methanone

参考文献

1. Patel MV, et al. Bioorg Med Chem. 2022 Jun 1;63:116743.

ABBV-318 (ABBV318)

生物&药学活性

物理化学性质&存储条件

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ABBV-318 (ABBV318)

生物&药学活性

物理化学性质&存储条件

参考文献

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