AB-423 |CAS:1572510-80-5 Probechem Biochemicals

Chemical Structure : AB-423

CAS No.: 1572510-80-5

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AB-423 (AB423;AB423)

货号: PC-63323Not For Human Use, Lab Use Only.

AB-423 is a novel potent, class II HBV capsid inhibitor that shows potent inhibition of HBV replication with EC50 of 0.08-0.27 uM, with no significant cytotoxicity (CC50>10 uM).

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10 mg	￥2180	In stock
25 mg	￥3780	In stock
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生物&药学活性

AB-423 (AB423) is a potent, class II HBV capsid inhibitor that shows potent inhibition of HBV replication with EC50 of 0.08-0.27 uM, with no significant cytotoxicity (CC50>10 uM).
AB-423 inhibits HBV genotypes A through D and nucleos/tide-resistant variants, causes capsid particles devoid of encapsidated pgRNA and rcDNA in treated HepDES19 cells.
AB-423 prevents the conversion of encapsidated rcDNA to cccDNA presumably by interfering with the capsid uncoating process.
AB-423 dose-dependently reduces serum HBV DNA levels in mouse model of HBV model, shows synergistic antiviral activity combined with entecavir (ETV).

物理化学性质&存储条件

分子量	386.389
分子式	C17H17F3N2O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-5-(N-(sec-butyl)sulfamoyl)-N-(3,4-difluorophenyl)-2-fluorobenzamide

参考文献

1. Mani N, et al. Antimicrob Agents Chemother. 2018 Mar 19. pii: AAC.00082-18.

AB-423 (AB423;AB423)

生物&药学活性

物理化学性质&存储条件

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AB-423 (AB423;AB423)

生物&药学活性

物理化学性质&存储条件

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