A452 | HDAC6 inhibitor | Probechem Biochemicals

Chemical Structure : A452

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A452 (HDAC6 inhibitor A452)

货号: PC-38796Not For Human Use, Lab Use Only.

A452 is a potent and selective HDAC6 inhibitor, effectively inhibits the cell growth and viability of various cancer cell types, irrespective of p53 status.

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生物&药学活性

A452 is a potent and selective HDAC6 inhibitor, effectively inhibits the cell growth and viability of various cancer cell types, irrespective of p53 status.
A452 induced apoptosis by activated caspase 3 and PARP, increased Bak and Bax and decreased Bcl-xL.
A452 increased wild-type p53 levels by destabilizing MDM2, but decreased mutant p53 by inducing MDM2 and inhibiting Hsp90-mutant p53 complex formation.
A452 blocked HDAC6 nuclear localization, resulting in increased levels of acetylated p53 at Lys381/382.
A452 disrupted the HDAC6-Hsp90 chaperone machinery via Hsp90 acetylation and degradation.
A452 chemosensitized cancer cells to the Hsp90 inhibitor 17-AAG.

物理化学性质&存储条件

分子量	338.407
分子式	C20H22N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-hydroxy-3-(1-(3-(naphthalen-2-yl)propyl)-2-oxo-2,5-dihydro-1H-pyrrol-3-yl)propanamide

参考文献

1. Ryu HW, et al. Planta Med. 2015 Feb;81(3):222-7.

2. Ryu HW, et al. Cancer Lett. 2017 Apr 10;391:162-171.

A452 (HDAC6 inhibitor A452)

生物&药学活性

物理化学性质&存储条件

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A452 (HDAC6 inhibitor A452)

生物&药学活性

物理化学性质&存储条件

参考文献

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