9-phenanthrol | TRPM4 inhibitor | Probechem Biochemicals

Chemical Structure : 9-phenanthrol

CAS No.: 484-17-3

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9-phenanthrol (9-Hydroxyphenanthrene, NSC 50554)

货号: PC-27188Not For Human Use, Lab Use Only.

9-Phenanthrol (9-Hydroxyphenanthrene) is a specific, reversible small molecule TRPM4 inhibitor with IC50 of 17 uM, is ineffective on the related channel TRPM5.

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50 mg	￥580	In stock
100 mg	￥880	In stock
250 mg	￥1280	In stock
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生物&药学活性

9-Phenanthrol (9-Hydroxyphenanthrene) is a specific, reversible small molecule TRPM4 inhibitor with IC50 of 17 uM, is ineffective on the related channel TRPM5.
9-phenanthrol blocks native TRPM4 currents in freshly isolated smooth muscle cells in a concentration-dependent manner (IC50=10.6 uM).
9-Phenanthrol (30 uM) has no effect on maximum evoked currents in human embryonic kidney cells expressing recombinant TRPC3 or TRPC6 channels.

物理化学性质&存储条件

分子量	194.23
分子式	C14H10O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Phenanthren-9-ol

参考文献

1. Simard C, et al. Br J Pharmacol. 2012 Apr;165(7):2354-64.

2. Grand T, et al. Br J Pharmacol. 2008 Apr;153(8):1697-705.

3. Gonzales AL, Am J Physiol Cell Physiol. 2010 Aug;299(2):C279-88.

9-phenanthrol (9-Hydroxyphenanthrene, NSC 50554)

生物&药学活性

物理化学性质&存储条件

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9-phenanthrol (9-Hydroxyphenanthrene, NSC 50554)

生物&药学活性

物理化学性质&存储条件

参考文献

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