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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Aurora Kinase-6K465
6K465

Chemical Structure : 6K465

CAS No.: 2702965-27-1

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6K465 (AURKA inhibitor 6K465)

货号: PC-22139Not For Human Use, Lab Use Only.

6K465 is a potent selective Aurora A (AURKA) inhibitor, effectively inhibits cancer cells overexpressing c-MYC- and/or N-MYC.

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5 mg ￥880 In stock
10 mg ￥1280 In stock
25 mg ￥2180 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

6K465 is a potent selective Aurora A (AURKA) inhibitor, effectively inhibits cancer cells overexpressing c-MYC- and/or N-MYC.
6K465 reduces levels of c-MYC and N-MYC oncoproteins more potently than alisertib.
6K465 dispalys potent antiproliferative effect an sensitivity against cell lung cancer (SCLC) and breast cancer (BC) cell lines with high protein levels of c-MYC and/or N-MYC.

物理化学性质&存储条件

分子量 542.05
分子式 C26H33ClFN9O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(3-Chloro-2-fluorophenyl)[4-[[4-(4-ethyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]amino]-1-piperidinyl]methanone

参考文献

1. Chang CP, et al. Mol Cancer Ther. 2024 Apr 9. doi: 10.1158/1535-7163.MCT-23-0602.

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