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首页-小分子抑制剂&激动剂-Others-Other Targets-5M-8OH-Q
5M-8OH-Q

Chemical Structure : 5M-8OH-Q

CAS No.: 312611-90-8

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5M-8OH-Q

货号: PC-21254Not For Human Use, Lab Use Only.

5M-8OH-Q is a specific small molecule inhibitor of UDP-glucose glycoprotein glucosyltransferase (UGGT), binds a CtUGGTGT24 “WY” conserved surface motif conserved across UGGTs (Kd=47 uM) but not present in other GT24 family glycosyltransferases.

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25 mg ￥1980 In stock
50 mg ￥2980 In stock
100 mg ￥4880 In stock
200 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

5M-8OH-Q is a specific small molecule inhibitor of UDP-glucose glycoprotein glucosyltransferase (UGGT), binds a CtUGGTGT24 “WY” conserved surface motif conserved across UGGTs (Kd=47 uM) but not present in other GT24 family glycosyltransferases.
5M-8OH-Q inhibits both UGGT1 and UGGT2 in cellula.
5M-8OH-Q is a useful starting point for the synthesis of UGGT modulator for the treatment of diseases caused by responsive mutants, as persistent UGGT-mediated glucosylation may prevent trafficking of slightly misfolded, but otherwise functional, glycoproteins to their correct cellular locations.

物理化学性质&存储条件

分子量 244.29
分子式 C14H16N2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-[(morpholin-4-yl)methyl]quinolin-8-ol

参考文献

1. Kevin P Guay, et al. iScience. 2023 Sep 20;26(10):107919.

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