5F-203 | AhR agonist | Probechem Biochemicals

Chemical Structure : 5F-203

CAS No.: 260443-89-8

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5F-203 (5F203, NSC 703786, NSC703786)

货号: PC-60776Not For Human Use, Lab Use Only.

5F 203 (NSC 703786) is a potent, selective antitumour agent through activation the aryl hydrocarbon receptor (AhR) pathway.

规格	价格	库存
10 mg	￥1280	In stock
25 mg	￥2280	In stock
50 mg	￥3980	In stock
100 mg	￥6580	In stock
200 mg		Get quote

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生物&药学活性

5F-203 (NSC 703786) is a potent, selective antitumour agent through activation the aryl hydrocarbon receptor (AhR) pathway.
5F-203 (NSC 703786) causes MCF-7 sensitive cells to arrest in G(1) and S phase, and induces DNA adduct formation, in contrast to AhR-deficient AH(R100) variant MCF-7 cells, induces CYP1A1 and CYP1B1 transcription.
L-lysylamide prodrug Phortress (NSC 710305) demonstrats antitumor activity in vivo.

物理化学性质&存储条件

分子量	258.314
分子式	C14H11FN2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole

参考文献

1. Bradshaw TD, et al. Mol Cancer Ther. 2002 Feb;1(4):239-46.

2. Gilbert J, et al. Mol Pharmacol. 2017 Dec 21. pii: mol.117.109827.

3. Trapani V, et al. Br J Cancer. 2003 Feb 24;88(4):599-605.

4. Leong CO, et al. Br J Cancer. 2003 Feb 10;88(3):470-7.

5F-203 (5F203, NSC 703786, NSC703786)

生物&药学活性

物理化学性质&存储条件

参考文献

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5F-203 (5F203, NSC 703786, NSC703786)

生物&药学活性

物理化学性质&存储条件

参考文献

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