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首页-小分子抑制剂&激动剂-GPCR-Sigma Receptor-4-PPBP
4-PPBP

Chemical Structure : 4-PPBP

CAS No.: 201216-39-9

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4-PPBP (PPBP)

货号: PC-61602Not For Human Use, Lab Use Only.

4-PPBP is a highly potent agonist of sigma 1 receptor (σ1 receptor) with Ki of 0.8 nM.

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10 mg ￥980 In stock
25 mg ￥1580 In stock
50 mg ￥2580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

4-PPBP is a highly potent agonist of sigma 1 receptor (σ1 receptor) with Ki of 0.8 nM.
4-PPBP attenuates activity of neuronal nitric oxide synthase (nNOS), blunts ischemia-induced nitric oxide production, and provides neuroprotection in stroke models.

物理化学性质&存储条件

分子量 293.454
分子式 C21H27N
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-phenyl-1-(4-phenylbutyl) piperidine

参考文献

1. Takahashi H, et al. Stroke. 1995 Sep;26(9):1676-82.

2. Narita N, et al. Eur J Pharmacol. 1995 Oct 6;293(3):277-80.

3. Yang ZJ, et al. Exp Neurol. 2010 Jan;221(1):166-74.

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