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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Proton Pump-2GBI
2GBI

Chemical Structure : 2GBI

CAS No.: 5418-95-1

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2GBI (2-guanidinobenzimidazole)

货号: PC-38295Not For Human Use, Lab Use Only.

2GBI (2-guanidinobenzimidazole) is a guanidine derivative that inhibits voltage-gated proton channel Hv1 by binding to the VSD from its intracellular side..

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

2GBI (2-guanidinobenzimidazole) is a guanidine derivative that inhibits voltage-gated proton channel Hv1 by binding to the VSD from its intracellular side.
2GBI also is an agonist directly targeting NLRP3, induces inflammasome activation, which is independent of potassium efflux, chloride efflux and mitochondrial dysfunction.

物理化学性质&存储条件

分子量 175.195
分子式 C8H9N5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-guanidinobenzimidazole

参考文献

1. Hong L, et al. Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9971-6.

2. Gianti E, et al. Proc Natl Acad Sci U S A. 2016 Dec 27;113(52):E8359-E8368.

3. Geragotelis AD, et al. Proc Natl Acad Sci U S A. 2020 Jun 16;117(24):13490-13498.

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