20(S)-Hydroxycholesterol | Hedgehog activator | Probechem Biochemicals

Chemical Structure : 20(S)-Hydroxycholesterol

CAS No.: 516-72-3

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20(S)-Hydroxycholesterol (20(S)-OHC)

货号: PC-62201Not For Human Use, Lab Use Only.

20(S)-Hydroxycholesterol is an allosteric activator of the Hedgehog signaling pathway Smoothened (Smo) oncoprotein, binds at a site distinct from the canonical cyclopamine binding site.

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生物&药学活性

20(S)-Hydroxycholesterol (20(S)-OHC) is an allosteric activator of the Hedgehog signaling pathway Smoothened (Smo) oncoprotein, binds at a site distinct from the canonical cyclopamine binding site.
20(S)-OHC activates Hedgehog (Hh) signaling (EC50 =3 uM for induction of Hh reporter gene transcription in in NIH 3T3 cells).
20(S)-OHC induces Smo accumulation in primary cilia.

物理化学性质&存储条件

分子量	402.65
分子式	C27H46O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	20α-hydroxy Cholesterol

参考文献

1. Nedelcu D, et al. Nat Chem Biol. 2013 Sep;9(9):557-64.

2. Nachtergaele S, et al. Nat Chem Biol. 2012 Jan 8;8(2):211-20.

3. Dwyer JR, et al. J Biol Chem. 2007 Mar 23;282(12):8959-68.

20(S)-Hydroxycholesterol (20(S)-OHC)

生物&药学活性

物理化学性质&存储条件

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20(S)-Hydroxycholesterol (20(S)-OHC)

生物&药学活性

物理化学性质&存储条件

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