2-Methoxyestradiol |CAS:362-07-2 Probechem Biochemicals

Chemical Structure : 2-Methoxyestradiol

CAS No.: 362-07-2

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2-Methoxyestradiol (2ME2;NSC-659853)

货号: PC-42847Not For Human Use, Lab Use Only.

规格	价格	库存
10 mg (Free Sample)	￥280	In stock
50 mg	￥880	In stock
100 mg	￥1280	In stock
250 mg	￥1880	In stock
1 g		Get quote

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生物&药学活性

2-Methoxyestradiol (2ME2, NSC-659853) is a metabolite of estradiol-17β and a novel antimitotic, antiangiogenic agent, binds to tubulin at or near the colchicine site and inhibits the polymerization of tubulin in vitro.
2-Methoxyestradiol suppresses microtubule dynamic instability in living interphase cells with mitotic IC50 of 1.2 uM, inhibits bFGF and VEGF-induced neovascularization and suppresses the growth of human breast carcinoma in mice.
2-Methoxyestradiol also downregulates hypoxia-inducible factor-1 (HIF-1) at the posttranscriptional level and inhibits HIF-1-induced transcriptional activation of VEGF expression.

物理化学性质&存储条件

分子量	302.4079
分子式	C19H26O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 36 mg/mL; H2O: < 0.1 mg/mL
Chemical Name/SMILES	Estra-1,3,5(10)-triene-3,17-diol, 2-methoxy-, (17.beta.)-

参考文献

1. Klauber N, et al. Mol Cancer Ther. 2006 Sep;5(9):2225-33.

2. Cushman M, et al. J Med Chem. 1995 Jun 9;38(12):2041-9.

3. Klauber N, et al. Cancer Res. 1997 Jan 1;57(1):81-6.

4. Mabjeesh NJ, et al. Cancer Cell. 2003 Apr;3(4):363-75.

2-Methoxyestradiol (2ME2;NSC-659853)

生物&药学活性

物理化学性质&存储条件

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2-Methoxyestradiol (2ME2;NSC-659853)

生物&药学活性

物理化学性质&存储条件

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