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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Eukaryotic Initiation Factor (eIF)-1Ai-8214
1Ai-8214

Chemical Structure : 1Ai-8214

CAS No.: 1014360-19-0

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1Ai-8214

货号: PC-24690Not For Human Use, Lab Use Only.

1Ai-8214 is a small molecule inhibitor of RPS10-eIF1A interaction, binds both eIF1A and RPS10.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

1Ai-8214 is a small molecule inhibitor of RPS10-eIF1A interaction, binds both eIF1A and RPS10.
1Ai-8214 decreases the development of ovarian cancer in OVCAR8 cell-derived xenograft (CDX) model.

物理化学性质&存储条件

分子量 366.80
分子式 C20H15ClN2O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(3-chloro-4,5-dihydroxyphenyl)-3-phenyl-2,3-dihydroquinazolin-4(1H)-one

参考文献

1. Hayat D, et al.EMBO J. 2025 May 12. doi: 10.1038/s44318-025-00449-6.

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