14-deoxy-11,12-didehydroandrographolide (DDA, DDHA)

Chemical Structure : 14-deoxy-11,12-didehydroandrographolide

CAS No.: 42895-58-9

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货号: PC-28516Not For Human Use, Lab Use Only.

14-deoxy-11,12-didehydroandrographolide (DDA, DDHA) is an andrographolide metabolite within antiviral, antipyretic, immunostimulant and anticancer activities, potently inhibits cannabidiol (CBD)-evoked TRPV3 activation with IC50 of 7 nM, modulates the immune system by regulating chemokine signaling, Rap1 signaling, cytokine-cytokine receptor interaction, MAPK signaling, NF-kappa B signaling, RAS signaling, p53 signaling, HIF-1 signaling, and natural killer cell-mediated cytotoxicity.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3280	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

14-deoxy-11,12-didehydroandrographolide (DDA, DDHA) is an andrographolide metabolite within antiviral, antipyretic, immunostimulant and anticancer activities, potently inhibits cannabidiol (CBD)-evoked TRPV3 activation with IC50 of 7 nM, modulates the immune system by regulating chemokine signaling, Rap1 signaling, cytokine-cytokine receptor interaction, MAPK signaling, NF-kappa B signaling, RAS signaling, p53 signaling, HIF-1 signaling, and natural killer cell-mediated cytotoxicity.

物理化学性质&存储条件

分子量	332.44
分子式	C20H28O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	14-deoxy-11,12-didehydroandrographolide

参考文献

1. Kumar RA, et al. J Ethnopharmacol. 2004 Jun;92(2-3):291-5.

2. Kalinovskii AP, et al. J Nat Prod. 2024 Jul 26;87(7):1852-1859.

3. Kalinovskii AP, et al. Cell Calcium. 2026 Oct 10;138:103201.

4. Khanal P, et al. RSC Adv. 2021 Jan 27;11(9):5065-5079.