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首页-小分子抑制剂&激动剂-Others-14-3-3 Protein-14-3-3-ERα stabilizer 41
14-3-3-ERα stabilizer 41

Chemical Structure : 14-3-3-ERα stabilizer 41

CAS No.:

14-3-3-ERα stabilizer 41

货号: PC-25264Not For Human Use, Lab Use Only.

14-3-3/ERα stabilizer 41 is a potent, selective and covalent small-molecule stabilizer of the 14-3-3σ/ERα complex, forms a covalent bond with C38 of 14-3-3σ, shows remarkable selectivity for 14-3-3σ/ERα (KD=10.1 nM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

14-3-3/ERα stabilizer 41 is a potent, selective and covalent small-molecule stabilizer of the 14-3-3σ/ERα complex, forms a covalent bond with C38 of 14-3-3σ, shows remarkable selectivity for 14-3-3σ/ERα (KD=10.1 nM).

物理化学性质&存储条件

分子量 436.92
分子式 C24H22ClFN4O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-chloro-N-(4-(3-((2,6-dimethylphenyl)amino)-6-methylimidazo[1,2-a]pyridin-2-yl)-3-fluorophenyl)acetamide

参考文献

1. Konstantinidou M, et al. Nat Commun. 2025 Jul 14;16(1):6467.

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