14-3-3-ERα stabilizer 181 | CAS 3057296-86-0 | Probechem Biochemicals

Chemical Structure : 14-3-3-ERα stabilizer 181

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14-3-3-ERα stabilizer 181 (14-3-3-ERα stabilizer)

货号: PC-25263Not For Human Use, Lab Use Only.

14-3-3/ERα stabilizer 181 is a potent, selective and covalent small-molecule stabilizer of the 14-3-3σ/ERα complex, forms a covalent bond with C38 of 14-3-3σ, shows remarkable selectivity for 14-3-3σ/ERα (appKD of 18 nM, 116-fold stabilization at 100 μM compound).

规格	价格	库存	数量
25 mg		Get quote
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100 mg		Get quote

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物理化学性质&存储条件

分子量	496.47
分子式	C25H35Cl2N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-chloro-1-(9-(4-((4-chlorophenyl)amino)-2,6-dimethyltetrahydro-2H-pyran-4-carbonyl)-3,9-diazaspiro[5.5]undecan-3-yl)ethan-1-one

参考文献

1. Konstantinidou M, et al. J Am Chem Soc. 2023 Sep 20;145(37):20328-20343.

14-3-3-ERα stabilizer 181 (14-3-3-ERα stabilizer)

生物&药学活性

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14-3-3-ERα stabilizer 181 (14-3-3-ERα stabilizer)

生物&药学活性

物理化学性质&存储条件

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