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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-TRP Channel-10-Shogaol
10-Shogaol

Chemical Structure : 10-Shogaol

CAS No.: 36752-54-2

10-Shogaol ([10]-Shogaol)

货号: PC-28016Not For Human Use, Lab Use Only.

10-Shogaol ([10]-Shogaol) is an active component of steamed ginger increases adrenaline secretion via the activation of TRPV1, also partially activates 5-HT1A receptor with Ki of 3-20 uM, also inhibits PMA-stimulated MDA-MB-231 cell invasion by reducing MMP-9 expression, also inhibits COX-2 with IC50 of 7.5 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

10-Shogaol ([10]-Shogaol) is an active component of steamed ginger increases adrenaline secretion via the activation of TRPV1, also partially activates 5-HT1A receptor with Ki of 3-20 uM, also inhibits PMA-stimulated MDA-MB-231 cell invasion by reducing MMP-9 expression, also inhibits COX-2 with IC50 of 7.5 uM.

物理化学性质&存储条件

分子量 332.48
分子式 C21H32O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-(4-Hydroxy-3-methoxyphenyl)tetradec-4-en-3-one

参考文献

1. Nievergelt A, et al. Bioorg Med Chem. 2010 May 1;18(9):3345-51.

2. Iwasaki Y, et al. Nutr Neurosci. 2006 Jun-Aug;9(3-4):169-78.

3. Ling H, et al. Br J Pharmacol. 2010 Dec;161(8):1763-77.

4. van Breemen RB, et al. Fitoterapia. 2011 Jan;82(1):38-43.

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