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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-TRP Channel-(rel)-ML-SI
(rel)-ML-SI

Chemical Structure : (rel)-ML-SI

CAS No.: 2108567-79-7

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(rel)-ML-SI (trans-ML-SI3)

货号: PC-73026Not For Human Use, Lab Use Only.

ML-SI3 (Mucolipin-specific synthetic inhibitor 3) is a synthetic antagonist of transient receptor potential mucolipin 1 (TRPML1), prevents lysosomal calcium efflux and blocks downstream TRPML1-mediated induction of autophagy.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

(rel)-ML-SI (Mucolipin-specific synthetic inhibitor 3) is a synthetic antagonist of transient receptor potential mucolipin 1 (TRPML1), prevents lysosomal calcium efflux and blocks downstream TRPML1-mediated induction of autophagy.
The TRPML1 inhibitor ML-SI3 binds the same cavity as its agonist ML-SA1.
ML-SI3 competes with ML-SA1 to block the channel activity.
ML-SI3 blocks TRPML1 channel activation yet does not inhibit PI(3,5)P2-dependent activation of the channel.
Transient receptor potential mucolipin 1 (TRPML1) regulates lysosomal calcium signaling, lipid trafficking, and autophagy-related processes.

物理化学性质&存储条件

分子量 429.579
分子式 C23H31N3O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

rel-N-((1R,2R)-2-(4-(2-Methoxyphenyl)piperazin-1-yl)cyclohexyl)benzenesulfonamide

参考文献

1. Philip Schmiege, et al. Structure. 2021 Nov 4;29(11):1295-1302.e3.

2. Li D, et al. Autophagy. 2021 Apr;17(4):872-887.

3. Leser C, et al. Eur J Med Chem. 2021 Jan 15;210:112966.

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