(Z)-LFM-A13

Chemical Structure : (Z)-LFM-A13

CAS No.: 244240-24-2

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货号: PC-45399Not For Human Use, Lab Use Only.

(Z)-LFM-A13 is a highly specific inhibitor of BTK with Ki of 1.4 uM, IC50 of 17.2 uM, shows no activity against EGFR, IRK, JAK1, JAK3, or HCK.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
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100 mg		Get quote

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生物&药学活性

(Z)-LFM-A13 is a highly specific inhibitor of BTK with Ki of 1.4 uM, IC50 of 17.2 uM, shows no activity against EGFR, IRK, JAK1, JAK3, or HCK.
LFM-A13 enhances the sensitivity to ceramide- or vincristine-induced apoptosis in BTK+ B-lineage leukemic cells; prolongs the median survival time of VPL-treated mice.
LFM-A13 also inhibits Plk3 with IC50 of 61 uM, prevented bipolar mitotic spindle assembly in human breast cancer cells and glioblastoma cells, delays tumor progression in MMTV/neu transgenic mouse model of HER2 positive breast cancer.

物理化学性质&存储条件

分子量	360.0014
分子式	C11H8Br2N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 42 mg/mL
Chemical Name/SMILES	2-Butenamide, 2-cyano-N-(2,5-dibromophenyl)-3-hydroxy-,(2Z)-

参考文献

1. Mahajan S, et al. J Biol Chem. 1999 Apr 2;274(14):9587-99.

2. Uckun FM, et al. Bioorg Med Chem. 2007 Jan 15;15(2):800-14.

3. Uckun FM, et al. Clin Cancer Res. 2002 May;8(5):1224-33.

(Z)-LFM-A13

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物理化学性质&存储条件

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