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首页-抗体药物偶连体和PROTACs-E3 Ligase Ligand-(S)-ACE-OH
(S)-ACE-OH

Chemical Structure : (S)-ACE-OH

CAS No.: 73644-43-6 (Rac)

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(S)-ACE-OH

货号: PC-23383Not For Human Use, Lab Use Only.

(S)-ACE-OH is a metabolite of acepromazin, acts as a molecular glue to induce an interaction between the E3 ubiquitin ligase TRIM21 and the nucleoporin NUP98, leading to the degradation of nuclear pore proteins and disruption of nucleocytoplasmic trafficking.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

(S)-ACE-OH is a metabolite of acepromazin, acts as a molecular glue to induce an interaction between the E3 ubiquitin ligase TRIM21 and the nucleoporin NUP98, leading to the degradation of nuclear pore proteins and disruption of nucleocytoplasmic trafficking.

物理化学性质&存储条件

分子量 328.47
分子式 C19H24N2OS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-1-(10-(3-(dimethylamino)propyl)-10H-phenothiazin-2-yl)ethan-1-ol

参考文献

1. Panrui Lu, et al. Cell. 2024 Oct 30:S0092-8674(24)01197-8.

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