(R)-9b | Ack1 inhibitor | ProbeChem Biochemicals

Chemical Structure : (R)-9b

CAS No.: 1655527-68-6

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(R)-9b (Ack1 inhibitor (R)-9b)

货号: PC-70152Not For Human Use, Lab Use Only.

Ack1 inhibitor (R)-9b is a potent and selective ACK1 (TNK2) inhibitor with IC50 of 48 nM.

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5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
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100 mg		Get quote

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生物&药学活性

Ack1 inhibitor (R)-9b is a potent and selective ACK1 (TNK2) inhibitor with IC50 of 48 nM.
(R)-9b also inhibits JAK2 (IC50=6 nM) and Tyk2 (IC50=5 nM), 3-fold selectvity over ALK and 10-fold over c-Src.
(R)-9b potently suppresses proliferation of human cancer cell lines with IC50 <2 uM.
(R)-9b exhibits considerable stability in human plasma and a long half-life.

物理化学性质&存储条件

分子量	402.927
分子式	C20H27ClN6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-5-chloro-N2-(4-(4-methylpiperazin-1-yl)phenyl)-N4-((tetrahydrofuran-2-yl)methyl)pyrimidine-2,4-diamine

参考文献

1. Mahajan K, et al. Cancer Cell. 2017 Jun 12;31(6):790-803.e8.

2. Wu X, et al. Oncotarget. 2017 Jan 10;8(2):2971-2983.

3. Lawrence HR, et al. J Med Chem. 2015 Mar 26;58(6):2746-63.

(R)-9b (Ack1 inhibitor (R)-9b)

生物&药学活性

物理化学性质&存储条件

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(R)-9b (Ack1 inhibitor (R)-9b)

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物理化学性质&存储条件

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