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(D)PPA-1 TFA

Chemical Structure : (D)PPA-1 TFA

CAS No.:

(D)PPA-1 TFA ((D)-PPA 1 TFA)

货号: PC-28254Not For Human Use, Lab Use Only.

(D)PPA-1 TFA ((D)-PPA 1 TFA) is a hydrolysis-resistant D-peptide antagonist of PD-1/PD-L1 interaction, binds PD-L1 at an affinity of 0.51 uM in vitro, inhibits PD-1/PD-L1 pathway in vivo.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

(D)PPA-1 TFA ((D)-PPA 1 TFA) is a hydrolysis-resistant D-peptide antagonist of PD-1/PD-L1 interaction, binds PD-L1 at an affinity of 0.51 uM in vitro, inhibits PD-1/PD-L1 pathway in vivo.

物理化学性质&存储条件

分子量 1669.67
分子式 C72H99F3N20O23
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

D-{Asn-Tyr-Ser-Lys-Pro-Thr-Asp-Arg-Gln-Tyr-His-Phe} TFA salt

参考文献

1. Chang HN, et al. Angew Chem Int Ed Engl. 2015 Sep 28;54(40):11760-4.

2. Feng Y, et al. Biomaterials. 2021 Aug;275:120990.

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